(Heparan sulfat)-glukozamin N-sulfotransferaza
| (heparan sulfat)-glukozamin N-sulfotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.8 | ||||||||
| CAS broj | 9026-75-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(heparan sulfat)-glukozamin N-sulfotransferaza (EC 2.8.2.8, heparinska N-sulfotransferaza, 3'-fosfoadenililsulfat:N-desulfoheparin sulfotransferaza, PAPS:N-desulfoheparin sulfotransferaza, PAPS:DSH sulfotransferaza, N-HSST, N-heparan sulfatna sulfotransferaza, heparan sulfat N-deacetilase/N-sulfotransferaza, heparan sulfatna 2-N-sulfotransferaza, heparan sulfatna N-sulfotransferaza, heparan sulfatna sulfotransferaza, N-desulfoheparinska sulfotransferaza, desulfoheparinska sulfotransferaza, 3'-fosfoadenilil-sulfat:N-desulfoheparin N-sulfotransferaza, heparitinska sulfotransferaza, 3'-fosfoadenilil-sulfat:heparitin N-sulfotransferaza) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin N-sulfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-N-sulfoglukozamin
Ovaj enzim takođe katalizuje sulfaciju hondroitin 4-sulfata i dermatan sulfata.
Reference[uredi | uredi kod]
- ↑ Suzuki, S., Trenn, R.H. and Strominger, J.L. (1961). „Separation of specific mucopolysaccharide sulfotransferases”. Biochim. Biophys. Acta 50: 169-174.
- ↑ Eisenman, R.A., Balasubramanian, A.S. and Marx, W. (1967). „3′-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction”. Arch. Biochem. Biophys. 119: 387-397. PMID 4964017.
- ↑ Johnson, A.H. and Baker, J.R. (1973). „The enzymatic sulphation of heparan sulphate by hen's uterus”. Biochim. Biophys. Acta 320: 341-351. PMID 4270798.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.