B-1,4-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza
(Preusmjereno sa stranice EC 2.4.1.144)
| B-1,4-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.144 | ||||||||
| CAS broj | 83744-93-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
B-1,4-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza (EC 2.4.1.144, N-acetilglukozaminiltransferaza III, N-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza III, uridin difosfoacetilglukozamin-glikopeptid beta4-acetilglukozaminiltransferaza III, beta-1,4-manozil-glikoprotein beta-1,4-N-acetilglukozaminiltransferaza, GnTIII) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-manozil-glikoprotein 4-beta-N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin + beta-D-manozil-R UDP + 4-(N-acetil-beta-D-glukozaminil)-beta-D-manozil-R
'R označava ostatak N-vezanog oligosaharida u glikoproteinskom akceptoru.
Reference[uredi | uredi kod]
- ↑ Narasimhan, S. (1982). „Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide β4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in β1-4 linkage to the β-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides”. J. Biol. Chem. 257: 10235-10242. PMID 6213618.
- ↑ Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. (1983). „Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type”. Methods Enzymol. 98: 98-134. PMID 6366476.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.