Protein-glutamat O-metiltransferaza
| Protein-glutamat O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.80 | ||||||||
| CAS broj | 2613562 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Protein-glutamat O-metiltransferaza (EC 2.1.1.80, metil-prihvatajuća hemotaksna proteinska O-metiltransferaza, S-adenozilmetionin-glutamil metiltransferaza, metil-prihvatajuća hemotaksna proteinska metiltransferaza II, S-adenozilmetionin:protein-karboksil O-metiltransferaza, proteinska metilaza II, MCP metiltransferaza I, MCP metiltransferaza II, proteinska O-metiltransferaza, protein(aspartat)metiltransferaza, protein(karboksil)metiltransferaza, proteinska karboksil-metilaza, proteinska karboksil-O-metiltransferaza, proteinska karboksilmetiltransferaza II, proteinska karboksimetilaza, proteinska karboksimetiltransferaza, proteinska metiltransferaza II) je enzim sa sistematskim imenom S-adenozil-L-metionin:protein-L-glutamat O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + protein L-glutamat S-adenozil-L-homocistein + protein L-glutamat metil estar
Ovaj enzim formira estarske grupe sa L-glutamatnim ostacima brojnih membranskih proteina.
Reference[uredi | uredi kod]
- ↑ Burgess-Cassler, A., Ulla, A.H.J. and Ordal, G.W. (1982). „Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II”. J. Biol. Chem. 257: 8412-8417. PMID 6806296.
- ↑ Kleene, S.J., Toews, M.L. and Adler, J. (1977). „Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis”. J. Biol. Chem. 252: 3214-3218. PMID 16888.
- ↑ Simms, S.A., Stock, A.M. and Stock, J.B. (1987). „Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria”. J. Biol. Chem. 262: 8537-8543. PMID 3298235.
- ↑ Springer, W.R. and Koshland, D.E., Jr. (1977). „Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system”. Proc. Natl. Acad. Sci. USA 74: 533-537. PMID 322131.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.