TRNK (guanin10-N2)-dimetiltransferaza
(Preusmjereno sa stranice EC 2.1.1.213)
| TRNK (guanin10-N2)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.213 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK (guanin10-N2)-dimetiltransferaza (EC 2.1.1.213, PAB1283, N(2),N(2)-dimetilguanozinska tRNK metiltransferaza, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzim) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin10-N2)-dimetiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + guanin10 u tRNK 2 S-adenozil-L-homocistein + N2-dimetilguanin10 u tRNK (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + guanin10 u tRNK S-adenozil-L-homocistein + N2-metilguanin10 u tRNK
- (1b) S-adenozil-L-metionin + N2-metilguanin10 u tRNK S-adenozil-L-homocistein + N2-dimetilguanin10 u tRNK
Reference[uredi | uredi kod]
- ↑ Armengaud, J., Urbonavicius, J., Fernandez, B., Chaussinand, G., Bujnicki, J.M. and Grosjean, H. (2004). „N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota”. J. Biol. Chem. 279: 37142-37152. PMID 15210688.
Literatura[uredi | uredi kod]
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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