Stearoil-KoA 9-desaturaza
(Preusmjereno sa stranice EC 1.14.19.1)
| Stearoil-KoA 9-desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.19.1 | ||||||||
| CAS broj | 9014-34-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Stearoil-KoA 9-desaturaza (EC 1.14.19.1, Delta9-desaturaza, acil-KoA desaturaza, masno kiselinska desaturaza, stearoil-KoA, vodonik-donor:kiseonik oksidoreduktaza) je enzim sa sistematskim imenom stearoil-KoA,ferocitohrom-b5:kiseonik oksidoreduktaza (9,10-devodonikacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- stearoil-KoA + 2 ferocitohrom b5 + O2 + 2 H+ oleoil-KoA + 2 fericitohrom b5 + 2H2O
Ovaj enzim sadrži gvožđe. Enzim iz jetre pacova je deo sistema koji obuhvata citohrom b5 i EC 1.6.2.2, citohrom-b5 reduktazu.
Reference[uredi | uredi kod]
- ↑ Fulco, A.J. and Bloch, K. (1964). „Cofactor requirements for the formation of Δ9-unsaturated fatty acids in Mycobacterium phlei”. J. Biol. Chem. 239: 993-997. PMID 14167617.
- ↑ Oshino, N., Imai, Y. and Sato, R. (1966). „Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes”. Biochim. Biophys. Acta 128: 13-27. PMID 4382040.
- ↑ Oshino, N., Imai, Y. and Sato, R. (1971). „A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes”. J. Biochem. (Tokyo) 69: 155-167. PMID 5543646.
- ↑ Strittmatter, P., Sputz, L., Corcoran, D., Rogers, M.J., Setlow, B. and Redline, R. (1974). „Purification and properties of rat liver microsomal stearyl coenzyme A desaturase”. Proc. Natl. Acad. Sci. USA 71: 4565-4569. PMID 4373719.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.