Gliceril-etar monooksigenaza
(Preusmjereno sa stranice EC 1.14.16.5)
| Gliceril-etar monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.16.5 | ||||||||
| CAS broj | 37256-82-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Gliceril-etar monooksigenaza (EC 1.14.16.5, gliceril-etarska monooksigenaza, enzim odvajanja gliceril-etra, gliceril etarska oksigenaza, glicerilna eteraza, O-alkilglicerolna monooksigenaza) je enzim sa sistematskim imenom 1-alkil-sn-glicerol,tetrahidrobiopterin:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 1-O-alkil-sn-glicerol + tetrahidrobiopterin + O2 1-O-(1-hidroksialkil)-sn-glicerol + dihidrobiopterin + H2O
Ovaj enzim razlaže alkilglicerole. Za njegovo dejstvo je neophodno gvožđe nevezano za hem, redukovani glutation i fosfolipidi.
Reference[uredi | uredi kod]
- ↑ Ishibashi, T. and Imai, Y. (1983). „Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes”. Eur. J. Biochem. 132: 23-27. PMID 6840084.
- ↑ Pfleger, E.C., Piantadosi, C. and Snyder, F. (1967). „The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species”. Biochim. Biophys. Acta 144: 633-648. PMID 4383918.
- ↑ Snyder, F., Malone, B. and Piantadosi, C. (1973). „Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity”. Biochim. Biophys. Acta 316: 259-265. PMID 4355017.
- ↑ Soodsma, J.F., Piantadosi, C. and Snyder, F. (1972). „Partial characterization of the alkylglycerol cleavage enzyme system of rat liver”. J. Biol. Chem. 247: 3923-3929. PMID 4402391.
- ↑ Tietz, A., Lindberg, M. and Kennedy, E.P. (1964). „A new pteridine-requiring enzyme system for the oxidation of glyceryl ethers”. J. Biol. Chem. 239: 4081-4090. PMID 14247652.
- ↑ Taguchi, H. and Armarego, W.L. (1998). „Glyceryl-ether monooxygenase [EC 1.14.16.5. A microsomal enzyme of ether lipid metabolism”]. Med. Res. Rev. 18: 43-89. PMID 9436181.
- ↑ Watschinger, K., Keller, M.A., Hermetter, A., Golderer, G., Werner-Felmayer, G. and Werner, E.R. (2009). „Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence”. Biol. Chem. 390: 3-10. PMID 19007315.
- ↑ Werner, E.R., Hermetter, A., Prast, H., Golderer, G. and Werner-Felmayer, G. (2007). „Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay”. J. Lipid Res. 48: 1422-1427. PMID 17303893.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.