Steroid 11b-monooksigenaza
(Preusmjereno sa stranice EC 1.14.15.4)
| Steroid 11b-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.15.4 | ||||||||
| CAS broj | 9029-66-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Steroid 11b-monooksigenaza (EC 1.14.15.4, steroidna 11beta-hidroksilaza, steroidna 11beta/18-hidroksilaza, oksigenaza, steroid 11beta -mono-) je enzim sa sistematskim imenom steroid,redukovani-adrenal-feredoksin:kiseonik oksidoreduktaza (11beta-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- steroid + redukovani adrenal feredoksin + O2 11beta-hidroksisteroid + oksidovani adrenal feredoksin + H2O
Ovaj enzim je hem-tiolatni protein (P-450). On takođe vrši hidroksilaciju steroida u 18-poziciji, i konvertuje 18-hidroksikortikosteron u aldosteron.
Reference[uredi | uredi kod]
- ↑ Grant, J.K. and Brownie, A.C. (1955). „The role of fumarate and TPN in steroid enzymic 11β-hydroxylation”. Biochim. Biophys. Acta 18: 433-434. PMID 13276417.
- ↑ Hayano, M. and Dorfman, R.I. (1954). „On the mechanism of the C-11β-hydroxylation of steroids”. J. Biol. Chem. 211: 227-235. PMID 13211659.
- ↑ Tomkins, G.M., Michael, P.J. and Curran, J.F. (1957). „Studies on the nature of steroid 11-β hydroxylation”. Biochim. Biophys. Acta 23: 655-656. PMID 13426185.
- ↑ Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. (1986). „The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis”. J. Biol. Chem. 261: 3556-3562. PMID 3485096.
- ↑ Zuidweg, M.H.J. (1968). „Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata”. Biochim. Biophys. Acta 152: 144-158. PMID 4967077.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.