Diacetil reduktaza (formira (R)-acetoin)
(Preusmjereno sa stranice EC 1.1.1.303)
| Diacetil reduktaza (formira (R)-acetoin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.303 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Diacetil reduktaza (formira (R)-acetoin) (EC 1.1.1.303, (R)-acetoinska dehidrogenaza) je enzim sa sistematskim imenom (R)-acetoin:NAD+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-acetoin + NAD+ diacetil + NADH + H+
Ova reakcija je katalizovana u reverznom smeru. Ta aktivnost je obično vezana za dejstvo butandiolne dehidrogenaze (EC 1.1.1.4 ili EC 1.1.1.76). Dok je dejstvo butandiolne dehidrogenaze reverzibilno, dejstvo diacetil reduktaze je ireverzibilno. Ovaj enzim je izražen u Saccharomyces cerevisiae. On se razlikuje od EC 1.1.1.304, diacetil reduktaze.
Reference[uredi | uredi kod]
- ↑ Heidlas, J. and Tressl, R. (1990). „Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae”. Arch. Microbiol. 154: 267-273. PMID 2222122.
- ↑ Gonzalez, E., Fernandez, M.R., Larroy, C., Sola, L., Pericas, M.A., Pares, X. and Biosca, J.A. (2000). „Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene”. J. Biol. Chem. 275: 35876-35885. PMID 10938079.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.