Dvolančana uracil-DNK glikozilaza
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| Dvolančana uracil-DNK glikozilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.28 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dvolančana uracil-DNK glikozilaza (EC 3.2.2.28, Mug, Dug, dsUDG, dvolančana DNK specifična UDG, dsDNK specifična UDG, UdgB, DNK glikozilaza specifična za G:T/U neusklađenost, UDG) je enzim sa sistematskim imenom uracil-dvolančana DNK dezoksiribohidrolaza (otpuštanje uracila).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa uracil
Ovaj enzim ne deluje na DNK koja sadrži T/G neusklađenost ili jednolančanu DNK koja sadrži bilo za-mesto-specifični uracil ili 3,N4-etenocitozinski ostatak.
Reference[uredi | uredi kod]
- ↑ Barrett, T.E., Scharer, O.D., Savva, R., Brown, T., Jiricny, J., Verdine, G.L. and Pearl, L.H. (1999). „Crystal structure of a thwarted mismatch glycosylase DNA repair complex”. EMBO J. 18: 6599-6609. PMID 10581234.
- ↑ Sung, J.S. and Mosbaugh, D.W. (2000). „Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV”. Biochemistry 39: 10224-10235. PMID 10956012.
- ↑ Mokkapati, S.K., Fernandez de Henestrosa, A.R. and Bhagwat, A.S. (2001). „Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells”. Mol. Microbiol. 41: 1101-1111. PMID 11555290.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.