Dugolančani enoil-KoA reduktaza
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| Dugolančani enoil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.93 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Dugolančani enoil-KoA reduktaza (EC 1.3.1.93, TSC13 (gen), CER10 (gen)) je enzim sa sistematskim imenom dugolančani acil-KoA:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dugolančani acil-KoA + NADP+ dugolančani trans-2,3-dehidroacil-KoA + NADPH + H+
Ovaj enzim je četvrta komponenta elongaze, mikrozomalnog proteinskog kompleksa koji je odgovoran za produžavanje palmitoila KoA i stearoila KoA (kao i njihovih modifikovanih formi) do dugolančanih acil KoA molekula.
Reference[uredi | uredi kod]
- ↑ Kohlwein, S.D., Eder, S., Oh, C.S., Martin, C.E., Gable, K., Bacikova, D. and Dunn, T. (2001). „Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae”. Mol. Cell Biol. 21: 109-125. PMID 11113186.
- ↑ Gable, K., Garton, S., Napier, J.A. and Dunn, T.M. (2004). „Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system”. J. Exp. Bot. 55: 543-545. PMID 14673020.
- ↑ Kvam, E., Gable, K., Dunn, T.M. and Goldfarb, D.S. (2005). „Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles”. Mol. Biol. Cell 16: 3987-3998. PMID 15958487.
- ↑ Zheng, H., Rowland, O. and Kunst, L. (2005). „Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis”. Plant Cell 17: 1467-1481. PMID 15829606.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.