Dualno specifična kinaza

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Dualno specifična kinaza
Identifikatori
EC broj 2.7.12.1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Dualno specifična kinaza (EC 2.7.12.1, ADK1, Arabidopsis dualno specifična kinaza 1, CLK1, dDYRK2, Mps1p) je enzim sa sistematskim imenom ATP:protein fosfotransferaza (Ser/Thr- and Tyr-fosforilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + protein \rightleftharpoons ADP + fosfoprotein

Ova familija enzima može da fosforiliše Ser/Thr i Tyr ostatke.

Reference[uredi - уреди]

  1. Ali, N., Halfter, U. and Chua, N.H. (1994). "Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine". J. Biol. Chem. 269: 31626–31629. PMID 7527390. 
  2. Lauze, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R. and Winey, M. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14: 1655–1663. PMID 7737118. 
  3. Menegay, H.J., Myers, M.P., Moeslein, F.M. and Landreth, G.E. (2000). "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell Sci. 113: 3241–3253. PMID 10954422. 
  4. Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K. and Cleghon, V. (2003). "dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila". Biochem. J. 374: 381–391. PMID 12786602. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]