Dolihil-difosfooligosaharid—protein glikotransferaza
| Dolihil-difosfooligosaharid---protein glikotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.18 | ||||||||
| CAS broj | 75302-32-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Dolihil-difosfooligosaharid---protein glikotransferaza (EC 2.4.99.18, dolihildifosfooligosaharid-protein glikoziltransferaza, asparagin N-glikoziltransferaza, dolihildifosfooligosaharid-protein oligosahariltransferaza, dolihilpirofosfodiacetilhitobioza-protein glikoziltransferaza, oligomanoziltransferaza, oligosaharid transferaza, dolihildifosforiloligosaharid-protein oligosahariltransferaza, dolihil-difosfooligosaharid:protein-L-asparagin oligopolisaharidotransferaza, STT3) je enzim sa sistematskim imenom dolihil-difosfooligosaharid:protein-L-asparagin N-beta-D-oligopolisaharidotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dolihil difosfooligosaharid + [protein]-L-asparagin [[dolihil difosfat] + glikoprotein sa oligosaharidnim lancom vezaim N-beta-D-glikozilnom vezom za protein L-asparagin
Ova reakcija se odvija kod eukariota koji formiraju glikoprotein transferom glukozil-manozil-glukozamin polisaharida na bočni-lanac L-asparaginskog ostatka u sekvenci -Asn-Xaa-Ser- ili -Asn-Xaa-Thr- (Xaa, a ne Pro) u polipeptidnim lancima.
Reference[uredi | uredi kod]
- ↑ Das, R.C. and Heath, E.C. (1980). „Dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase; solubilization, purification, and properties”. Proc. Natl. Acad. Sci. USA 77: 3811-3815. PMID 6933437.
- ↑ Song, W., Henquet, M.G., Mentink, R.A., van Dijk, A.J., Cordewener, J.H., Bosch, D., America, A.H. and van der Krol, A.R. (2011). „N-glycoproteomics in plants: perspectives and challenges”. J Proteomics 74: 1463-1474. PMID 21605711.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.