Diizopropilna fluorofosfataza
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| Diizopropilna fluorofosfataza | |||||||||
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| Diizopropilna fluorofosfataza monomer, Loligo vulgaris | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.1.8.2 | ||||||||
| CAS broj | 9032-18-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Diizopropilna fluorofosfataza (EC 3.1.8.2, DFPaza, tabunaza, somanaza, organofosforno kiselinska anhidrolaza, organofosfat kiselinska anhidraza, OPA anhidraza, diizopropilfosfofluoridaza, dialkilfluorofosfataza, diizopropil fosforofluoridatna hidrolaza, izopropilfosforofluoridaza, diizopropilfluorofosfonatna dehalogenaza) je enzim sa sistematskim imenom diizopropil-fluorofosfat fluorohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- diizopropil fluorofosfat + H2O diizopropil fosfat + fluorid
Ovaj enzim deluje na fosforne anhidridne veze (poput fosfor-halida i fosfor-cijanida) u organofosfornim jedinjenjima (uključujući 'nervne gasove').
Reference[uredi | uredi kod]
- ↑ Augustinsson, K.-B. and Heimburger, G. (1954). „Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun)”. Acta Chem. Scand. 8: 753-761.
- ↑ Augustinsson, K.-B. and Heimburger, G. (1954). „Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase”. Acta Chem. Scand. 8: 762-767.
- ↑ Augustinsson, K.-B. and Heimburger, G. (1954). „Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies”. Acta Chem. Scand. 8: 1533-1541.
- ↑ Cohen, J.A. and Warringa, M.G.P.J. (1957). „Purification and properties of dialkylfluorophosphatase”. Biochim. Biophys. Acta 26: 29-39. PMID 13479457.
- ↑ Mounter, L.A. (1960). „Enzymic hydrolysis of organophosphorus compounds”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 541-550.
- ↑ Reiner, E., Aldridge, W.N. and Hoskin, C.G., ur. (1989). Enzymes Hydrolysing Organophosphorus Compounds. Chichester, UK: Ellis Horwood. str. -.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Reiner, E., Aldridge, W.N. and Hoskin, C.G., ur. (1989). Enzymes Hydrolysing Organophosphorus Compounds. Chichester, UK: Ellis Horwood. str. -.
- Mounter, L.A. (1960). „Enzymic hydrolysis of organophosphorus compounds”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 4 (2nd izd.). New York: Academic Press. str. 541-550.