Diguanilat ciklaza
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| Diguanilat ciklaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.65 | ||||||||
| CAS broj | 146316-82-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Diguanilat ciklaza (EC 2.7.7.65, DGC, PleD) je enzim sa sistematskim imenom GTP:GTP guanililtransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 GTP 2 difosfat + ciklična di-3',5'-guanilat
Ovaj protein sadrži GGDEF-domen. Za njegov rad je neophodan jon Mg2+ ili Mn2+.
Reference[uredi | uredi kod]
- ↑ Ryjenkov, D.A., Tarutina, M., Moskvin, O.V. and Gomelsky, M. (2005). „Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain”. J. Bacteriol. 187: 1792-1798. PMID 15716451.
- ↑ Méndez-Ortiz, M.M., Hyodo, M., Hayakawa, Y. and Membrillo-Hernández, J. (2006). „Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3′,5′-cyclic diguanylic acid”. J. Biol. Chem. 281: 8090-8099. PMID 16418169.
- ↑ Paul, R., Abel, S., Wassmann, P., Beck, A., Heerklotz, H. and Jenal, U. (2007). „Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization”. J. Biol. Chem. 282: 29170-29177. PMID 17640875.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.