Diftin—amonijačna ligaza
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| Diftin—amonijačna ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.1.14 | ||||||||
| CAS broj | 114514-33-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Diftin—amonijačna ligaza (EC 6.3.1.14, diftamidna sintaza, diftamidna sintetaza) je enzim sa sistematskim imenom diftin:amonijak ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ova amidaza katalizuje zadnji korak konverzije L-histidinskog ostatka u translation elongacionom faktoru eEF-2 do diftamida.
Reference[uredi | uredi kod]
- ↑ Moehring, J.M. and Moehring, T.J. (1988). „The post-translational trimethylation of diphthamide studied in vitro”. J. Biol. Chem. 263: 3840-3844. PMID 3346227.
- ↑ Moehring, T.J. and Moehring, J.M. (1987). „Mutant cultured cells used to study the synthesis of diphthamide”. UCLA Symp. Mol. Cell. Biol. New Ser. 45: 53-63.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.