Dezoksiholna kiselina

Dezoksiholna kiselina
	(3α,5β,12α,20R)-3,12-dihidroksiholan-24-oinska kiselina
Drugi nazivi	Dezoksiholat
Identifikacija
CAS registarski broj	83-44-3
PubChem	222528
ChemSpider	193196
UNII	005990WHZZ
DrugBank	DB07690
ChEBI	28834
ChEMBL	CHEMBL406393
Jmol-3D slike	Slika 1
SMILES
	C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
InChI
	InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1 ; Kod: KXGVEGMKQFWNSR-LLQZFEROSA-N InChI=1/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1; Kod: KXGVEGMKQFWNSR-LLQZFEROBK
Svojstva
Molekulska formula	C24H40O4
Molarna masa	392.57 g mol−1
Tačka topljenja	174 - 176 °C
Rastvorljivost u vodi	0,24%
pKa	6,58
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Dezoksiholna kiselina (dezoksiholat, holanoinska kiselina, 3α,12α-dihidroksi-5β-holanat) je žučna kiselina.^[7]^[8] Dezoksiholna kiselina je pripadnik grupe sekundarnih žučnih kiselina, koje su metabolički nusprodukti intestinalnih bakterija. Dve primarne žučne kiseline koje se izlučuju iz jetre su holna kiselina i henodezoksiholna kiselina. Bakterije metabolišu henodezoksiholnu kiselinu u sekundarnu žučnu kiselinu, litoholnu kiselinu, i holnu kiselinu u dezoksiholnu kiselinu.

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Product information sheet from Sigma Aldrich: http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/d2510pis.Par.0001.File.tmp/d2510pis.pdf Arhivirano 2020-06-06 na Wayback Machine-u
↑ Lide, David R. (1998). Handbook of Chemistry and Physics (87 izd.). CRC Press. str. 1287. ISBN 0-8493-0594-2.
↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Product information sheet from Sigma Aldrich: http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/d2510pis.Par.0001.File.tmp/d2510pis.pdf Arhivirano 2020-06-06 na Wayback Machine-u

[hand-6] Lide, David R. (1998). Handbook of Chemistry and Physics (87 izd.). CRC Press. str. 1287. ISBN 0-8493-0594-2.

[7] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.

[8] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.

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Dezoksiholna kiselina

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