Demetilsferoiden O-metiltransferaza
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| Demetilsferoiden O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.210 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Demetilsferoiden O-metiltransferaza (EC 2.1.1.210, 1-hidroksikarotenoidna O-metilaza, 1-hidroksikarotenoidna metilaza, 1-HO-karotenoidna metilaza, CrtF) je enzim sa sistematskim imenom S-adenozil-L-metionin:demetilsferoiden O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + demetilsferoiden S-adenozil-L-homocistein + sferoiden
Kod Rhodopseudomonas capsulata i Rubrivivax gelatinosus ovaj enzim učestvuje u biosintezi sferoidena. Kod Rubrivivax gelatinosus on takođe katalizuje metilaciju demetilspiriloksantina do spiriloksantin, i metilaciju 3,4-didehidrorodopina do anhidrorodovibrina.
Reference[uredi | uredi kod]
- ↑ Badenhop, F., Steiger, S., Sandmann, M. and Sandmann, G. (2003). „Expression and biochemical characterization of the 1-HO-carotenoid methylase CrtF from Rhodobacter capsulatus”. FEMS Microbiol. Lett. 222: 237-242. PMID 12770713.
- ↑ Pinta, V., Ouchane, S., Picaud, M., Takaichi, S., Astier, C. and Reiss-Husson, F. (2003). „Characterization of unusual hydroxy- and ketocarotenoids in Rubrivivax gelatinosus: involvement of enzyme CrtF or CrtA”. Arch. Microbiol. 179: 354-362. PMID 12664193.
- ↑ Scolnik, P.A., Walker, M.A. and Marrs, B.L. (1980). „Biosynthesis of carotenoids derived from neurosporene in Rhodopseudomonas capsulata”. J. Biol. Chem. 255: 2427-2432. PMID 7358679.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.