Deacetoksicefalosporin-C sintaza
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| Deacetoksicefalosporin-C sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.20.1 | ||||||||
| CAS broj | 85746-10-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Deacetoksicefalosporin-C sintaza (EC 1.14.20.1, DAOCS, penicilinska N ekspandaza, DAOC sintaza) je enzim sa sistematskim imenom penicilin-N,2-oksoglutarat:kiseonik oksidoreduktaza (ekspanzija prstena).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim učestvuje u biosintezi penicilina.
Reference[uredi | uredi kod]
- ↑ Cantwell, C., Beckmann, R., Whiteman, P., Queener, S.W. and Abraham, E.P. (1992). „Isolation of deacetoxycephalosporin-c from fermentation broths of Penicillium chrysogenum transformants - construction of a new fungal biosynthetic-pathway”. Proc. R. Soc. Lond. B Biol. Sci. 248: 283-289. PMID 1354366.
- ↑ Lee, H.J., Lloyd, M.D., Harlos, K., Clifton, I.J., Baldwin, J.E. and Schofield, C.J. (2001). „Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)”. J. Mol. Biol. 308: 937-948. PMID 11352583.
- ↑ Yeh, W.K., Ghag, S.K. and Queener, S.W. (1992). „Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3′-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering”. Ann. N.Y. Acad. Sci. 672: 396-408.
- ↑ Valegaard, K., van Scheltinga, A.C.T., Lloyd, M.D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H.-J., Baldwin, J.E., Schofield, C.J., Hajdu, J. and Andersson, I. (1998). „Structure of a cephalosporin synthase”. Nature 394: 805-809. PMID 9723623.
- ↑ Dotzlaf, J.E. and Yeh, W.K. (1989). „Purification and properties of deacetoxycephalosporin C synthase from recombinant Escherichia coli and its comparison with the native enzyme purified from Streptomyces clavuligerus”. J. Biol. Chem. 264: 10219-10227. PMID 2656705.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.