DTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza N,N-dimetiltransferaza
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| DTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza N,N-dimetiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.1.1.234 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza N,N-dimetiltransferaza (EC 2.1.1.234, DesVI) je enzim sa sistematskim imenom S-adenozil-L-metionin:dTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza 3-N,N-dimetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + dTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza 2 S-adenozil-L-homocistein + dTDP-3-dimetilamino-3,4,6-tridezoksi-alfa-D-glukopiranoza
Ovaj enzim učestvuje u biosintezi desosamina, 3-(dimetilamino)-3,4,6-tridezoksiheksoze prisutne u pojedinim makrolidnim antibioticima kao što je ertiromicin, azitromicin, i klaritromicin.
Reference[uredi | uredi kod]
- ↑ Chen, H., Yamase, H., Murakami, K., Chang, C.W., Zhao, L., Zhao, Z. and Liu, H.W. (2002). „Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine”. Biochemistry 41: 9165-9183. PMID 12119032.
- ↑ Burgie, E.S. and Holden, H.M. (2008). „Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis”. Biochemistry 47: 3982-3988. PMID 18327916.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.