DNK (citozin-5-)-metiltransferaza

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DNK (citozin-5-)-metiltransferaza
PDB 2ar0 EBI.jpg
Identifikatori
EC broj 2.1.1.37
CAS broj 9037-42-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

DNK (citozin-5-)-metiltransferaza (EC 2.1.1.37, EcoRI metilaza, DNK 5-citozinska metilaza, DNK citozinska C5 metilaza, DNK citozinska metilaza, DNK metilaza, DNK metiltransferaza, DNK transmetilaza, DNK-citozinska 5-metilaza, DNK-citozinska metiltransferaza, HpaII metilaza, HpaII' metilaza, M.BsuRIa, M.BsuRIb, Tip II DNK metilaza, citozinska 5-metiltransferaza, citozinska DNK metilaza, citozinska DNK metiltransferaza, citozin-specifična DNK metiltransferaza, dezoksiribonukleinska metilaza, dezoksiribonukleinska metiltransferaza, dezoksiribonukleinska (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina (citozin-5-)-metiltransferaza, dezoksiribonukleinska kiselina metilaza, dezoksiribonukleinska kiselina metiltransferaza, metilaza modifikacije dezoksiribonukleinske kiseline, dezoksiribonukleinska metilaza, metilfosfotriester-DNK metiltransferaza, modifikaciona metilaza, restrikciono-modifikacioni sistem, site-specifična DNK-metiltransferaza (citozin-specifična), DNK-(citozin C5)-metilaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:DNK (citozin-5-)-metiltransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + DNK citozin S-adenozil-L-homocistein + DNK 5-metilcitozin

Reference[uredi - уреди | uredi izvor]

  1. Gold, M. and Hurwitz, J. (1964). "The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. V. Purification and properties of the deoxyribonucleic acid-methylating activity of Escherichia coli". J. Biol. Chem. 239: 3858–2865. PMID 14257620. 
  2. Kalousek, F. and Morris, N.R. (1969). "The purification and properties of deoxyribonucleic acid methylase from rat spleen". J. Biol. Chem. 244: 1157–1163. PMID 4975067. 
  3. Roy, P.H. and Weissbach, A. (1975). "DNA methylase from HeLa cell nuclei". Nucleic Acids Res. 2: 1669–1684. PMID 1187340. 
  4. Simon, D., Grunert, F., Acken, U.Y., Döring, H.P. and Kröger, H. (1978). "DNA-methylase from regenerating rat liver: purification and characterisation". Nucleic Acids Res. 5: 2153–2167. PMID 673848. 
  5. Sneider, T.W., Teague, W.M. and Rogachewsky, L.M. (1975). "S-Adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line". Nucleic Acids Res. 2: 1685–1700. PMID 171625. 
  6. Turnbull, J.F. and Adams, R.L.P. (1976). "DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity". Nucleic Acids Res. 3: 677–695. PMID 131936. 
  7. Kessler, C. and Manta, V. (1990). "Specificity of restriction endonucleases and DNA modification methyltransferases: a review". Gene 92: 1–248. PMID 2172084. 
  8. Roberts, R.J. (1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Res. 18: 2331–2365. PMID 2159140. 
  9. Yuan, R. (1981). "Structure and mechanism of multifunctional restriction endonucleases". Annu. Rev. Biochem. 50: 285–319. PMID 6267988. 

Literatura[uredi - уреди | uredi izvor]

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