D-stereospecifična aminopeptidaza
Prijeđi na navigaciju
Prijeđi na pretragu
D-stereospecifična aminopeptidaza | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifikatori | |||||||||
EC broj | 3.4.11.19 | ||||||||
CAS broj | 57534-78-8 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
|
D-stereospecifična aminopeptidaza (EC 3.4.11.19, D-aminopeptidaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalne D-aminokiseline sa peptida, Xaa-Yaa-, gde je Xaa preferentno D-Ala, D-Ser ili D-Thr. Amidi D-aminokiselina i metilni estri se takođe hidrolizuju, kao i glicinski amid
Ovaj enzim je izolovan iz bakterije Ochrobactrum anthropi.
Reference[uredi | uredi kod]
- ↑ Asano, Y., Nakazawa, A., Kato, Y. and Kondo, K. (1989). „Properties of a novel D-stereospecific aminopeptidase from Ochrobactrum anthropi”. J. Biol. Chem. 264: 14233-14239. PMID 2760064.
- ↑ Asano, Y., Kato, Y., Yamada, A. and Kondo, K. (1992). „Structural similarity of D-aminopeptidase to carboxypeptidase DD and β-lactamases”. Biochemistry 31: 2316-2328. PMID 1540587.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.