D-inozitol-3-fosfat glikoziltransferaza
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| D-inozitol-3-fosfat glikoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.250 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D-inozitol-3-fosfat glikoziltransferaza (EC 2.4.1.250, mikotiolna glikoziltransferazas, MshA) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:1D-mio-inozitol 3-fosfat alfa-D-glikosiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin + 1D-mio-inozitol 3-fosfat 1-O-(2-acetamido-2-dezoksi-alfa-D-glukopiranozil)-1D-mio-inozitol 3-fosfat + UDP
Ovaj enzim katalizuje prvu reakciju u biosintezi mikotiola.
Reference[uredi | uredi kod]
- ↑ Newton, G.L., Koledin, T., Gorovitz, B., Rawat, M., Fahey, R.C. and Av-Gay, Y. (2003). „The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)”. J. Bacteriol. 185: 3476-3479. PMID 12754249.
- ↑ Newton, G.L., Ta, P., Bzymek, K.P. and Fahey, R.C. (2006). „Biochemistry of the initial steps of mycothiol biosynthesis”. J. Biol. Chem. 281: 33910-33920. PMID 16940050.
- ↑ Vetting, M.W., Frantom, P.A. and Blanchard, J.S. (2008). „Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis”. J. Biol. Chem. 283: 15834-15844. PMID 18390549.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.