D-glicero-beta-D-mano-heptoza-7-fosfat kinaza
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| D-glicero-beta-D-mano-heptoza-7-fosfat kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.167 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D-glicero-beta-D-mano-heptoza-7-fosfat kinaza (EC 2.7.1.167, heptoza 7-fosfatna kinaza, D-beta-D-heptozna 7-fosfotransferaza, D-beta-D-heptoza-7-fosfatna kinaza, HldE1 heptokinaza, glicero-mano-heptozna 7-fosfat kinaza, D-beta-D-heptoza 7-fosfatna kinaza/D-beta-D-heptoza 1-fosfat adenililtransferaza, hldE (gen), rfaE (gen)) je enzim sa sistematskim imenom ATP:D-glicero-beta-D-mano-heptoza 7-fosfat 1-fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj bifunkcionalani protein hldE deluje kao D-glicero-beta-D-mano-heptoza-7-fosfatna kinaza i D-glicero-beta-D-mano-heptoza 1-fosfat adenililtransferaza (cf. EC 2.7.7.70).
Reference[uredi | uredi kod]
- ↑ McArthur, F., Andersson, C.E., Loutet, S., Mowbray, S.L. and Valvano, M.A. (2005). „Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis”. J. Bacteriol. 187: 5292-5300. PMID 16030223.
- ↑ Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. (2002). „Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli”. J. Bacteriol. 184: 363-369. PMID 11751812.
- ↑ Valvano, M.A., Messner, P. and Kosma, P. (2002). „Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides”. Microbiology 148: 1979-1989. PMID 12101286.
- ↑ Jin, U.H., Chung, T.W., Lee, Y.C., Ha, S.D. and Kim, C.H. (2001). „Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium”. Glycoconj. J. 18: 779-787. PMID 12441667.
- ↑ Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. (2010). „Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)”. Biochemistry 49: 1072-1081. PMID 20050615.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.