D-Ala-D-Ala dipeptidaza

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D-Ala-D-Ala dipeptidaza
EC broj
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

D-Ala-D-Ala dipeptidaza (EC, D-alanil-D-alanin dipeptidaza, vanX D-Ala-D-Ala dipeptidaza, VanX) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-Ala-D-Ala + H2O 2 D-Ala

Ovaj enzim je zavistan od Zn2+ jona.

Reference[uredi - уреди | uredi izvor]

  1. Reynolds, P.E., Depardieu, F., Dutka-Malen, S., Arthur, M. and Courvalin, P. (1994). "Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine". Mol. Microbiol. 13: 1065–1070. PMID 7854121. 
  2. Wu, Z., Wright, G.D. and Walsh, C.T. (1995). "Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147". Biochemistry 34: 2455–2463. PMID 7873524. 
  3. McCafferty, D.G., Lessard, I.A. and Walsh, C.T. (1997). "Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX". Biochemistry 36: 10498–10505. PMID 9265630. 
  4. Bussiere, D.E., Pratt, S.D., Katz, L., Severin, J.M., Holzman, T. and Park, C.H. (1998). "The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance". Mol. Cell. 2: 75–84. PMID 9702193. 
  5. Tan, A.L., Loke, P. and Sim, T.S. (2002). "Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2)". Res. Microbiol. 153: 27–32. PMID 11881895. 
  6. Matthews, M.L., Periyannan, G., Hajdin, C., Sidgel, T.K., Bennett, B. and Crowder, M.W. (2006). "Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme". J. Am. Chem. Soc. 128: 13050–13051. PMID 17017774. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]