Cistein sintaza

Izvor: Wikipedia
Cistein sintaza
Identifikatori
EC broj 2.5.1.47
CAS broj 37290-89-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Cistein sintaza (EC 2.5.1.47, O-acetil-L-serin sulfhidrilaza, O-acetil-L-serin sulfohidrolaza, O-acetilserin (tiol)-lijaza, O-acetilserin (tiol)-lijaza A, O-acetilserin sulfhidrilaza, O3-acetil-L-serin acetat-lijaza (dodaje vodonik-sulfid), acetilserin sulfhidrilaza, cistein sintetaza, S-sulfocistein sintaza, 3-O-acetil-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza) je enzim sa sistematskim imenom O3-acetil-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

O3-acetil-L-serin + vodonik sulfid \rightleftharpoons L-cistein + acetat

Ovaj enzim je piridoksal-fosfatni protein. Pojedini alkilni tioli, cijanidi, pirazoli i neka druga heterociklična jedinjenja mogu da deluju kao akceptori.

Reference[uredi - уреди]

  1. Becker, M.A., Kredich, N.M. and Tomkins, G.M. (1969). "The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium". J. Biol. Chem. 244: 2418-2427. PMID 4891157. 
  2. Hara, S., Payne, M.A., Schnackerz, K.D. and Cook, P.F. (1990). "A rapid purification procedure and computer-assisted sulfide ion selective electrode assay for O-acetylserine sulfhydrylase from Salmonella typhimurium". Protein Expr. Purif. 1: 70-76. PMID 2152186. 
  3. Ikegami, F., Kaneko, M., Lambein, F., Kuo, Y.-H. and Murakoshi, I. (1987). "Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum". Phytochemistry 26: 2699-2704. 
  4. Murakoshi, I., Kaneko, M., Koide, C. and Ikegami, F. (1986). "Enzymatic-synthesis of the neuroexcitatory amino-acid quisqualic by cysteine synthase". Phytochemistry 25: 2759-2763. 
  5. Tai, C.H., Burkhard, P., Gani, D., Jenn, T., Johnson, C. and Cook, P.F. (2001). "Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase". Biochemistry 40: 7446-7452. PMID 11412097. 
  6. Bettati, S., Benci, S., Campanini, B., Raboni, S., Chirico, G., Beretta, S., Schnackerz, K.D., Hazlett, T.L., Gratton, E. and Mozzarelli, A. (2000). "Role of pyridoxal 5′-phosphate in the structural stabilization of O-acetylserine sulfhydrylase". J. Biol. Chem. 275: 40244-40251. PMID 10995767. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]