Cistationin g-sintaza

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Cistationin g-sintaza
EC broj
CAS broj 9030-70-0
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Cistationin g-sintaza (EC, O-sukcinil-L-homoserin sukcinat-lijaza (dodaje cistein), O-sukcinilhomoserin (tiol)-lijaza, homoserin O-transsukcinilaza, O-sukcinilhomoserin sintaza, O-sukcinilhomoserin sintetaza, cistationinska sintaza, cistationinska sintetaza, homoserinska transsukcinilaza, 4-O-sukcinil-L-homoserin:L-cistein S-(3-amino-3-karboksipropil)transferaza) je enzim sa sistematskim imenom O4-sukcinil-L-homoserin:L-cistein S-(3-amino-3-karboksipropil)transferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

O4-sukcinil-L-homoserin + L-cistein \rightleftharpoons L-cistationin + sukcinat

Ovaj enzim je piridoksal-fosfatni protein. On takođe reaguje sa vodonik sulfidom i metantiolom.

Reference[uredi - уреди]

  1. Flavin, M. and Slaughter, C. (1967). "Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine". Biochim. Biophys. Acta 132: 400–405. PMID 5340123. 
  2. Kaplan, M.M. and Flavin, M. (1966). "Cystathionine γ-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis". J. Biol. Chem. 241: 4463–4471. PMID 5922970. 
  3. Wiebers, J.L. and Garner, H.R. (1967). "Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity". J. Biol. Chem. 242: 12–23. PMID 6016326. 
  4. Wiebers, J.L. and Garner, H.R. (1967). "Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli". J. Biol. Chem. 242: 5644–5649. PMID 12325384. 
  5. Clausen, T., Huber, R., Prade, L., Wahl, M.C. and Messerschmidt, A. (1998). "Crystal structure of Escherichia coli cystathionine γ-synthase at 1.5 Å resolution". EMBO J. 17: 6827–6838. PMID 9843488. 
  6. Ravanel, S., Gakiere, B., Job, D. and Douce, R. (1998). "Cystathionine γ-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli". Biochem. J. 331: 639–648. PMID 9531508. 

Literatura[uredi - уреди]

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