Cijanohidrin b-glukoziltransferaza
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| Cijanohidrin b-glukoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.85 | ||||||||
| CAS broj | 55354-52-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Cijanohidrin b-glukoziltransferaza (EC 2.4.1.85, uridin difosfoglukoza-p-hidroksimandelonitrilna glukoziltransferaza, UDP-glukoza-p-hidroksimandelonitrilna glukoziltransferaza, uridin difosfoglukoza-cijanohidrinska glukoziltransferaza, uridin difosfoglukoza:aldehid cijanohidrin beta-glukoziltransferaza, UDP-glukoza:(S)-4-hidroksimandelonitrilna beta-D-glukoziltransferaza, UGT85B1, UDP-glukoza:p-hidroksimandelonitril-O-glukoziltransferaza) je enzim sa sistematskim imenom UDP-D-glukoza:(S)-4-hidroksimandelonitril beta-D-glukoziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-D-glukoza + (S)-4-hidroksimandelonitril UDP + (S)-4-hidroksimandelonitril beta-D-glukozid
Ovaj enzim deluje na širok opseg supstrata in vitro, uključujući cijanohidrine, terpenoide, fenolne, heksanolne derivate i biljne hormone.
Reference[uredi | uredi kod]
- ↑ Reay, P.F. and Conn, E.E. (1974). „The purification and properties of a uridine diphosphate glucose: aldehyde cyanohydrin β-glucosyltransferase from sorghum seedlings”. J. Biol. Chem. 249: 5826-5830. PMID 4416442.
- ↑ Jones, P.R., Møller, B.L. and Hoj, P.B. (1999). „The UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase that catalyzes the last step in synthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor. Isolation, cloning, heterologous expression, and substrate specificity”. J. Biol. Chem. 274: 35483-35491. PMID 10585420.
- ↑ Hansen, K.S., Kristensen, C., Tattersall, D.B., Jones, P.R., Olsen, C.E., Bak, S. and Møller, B.L. (2003). „The in vitro substrate regiospecificity of recombinant UGT85B1, the cyanohydrin glucosyltransferase from Sorghum bicolor”. Phytochemistry 64: 143-151. PMID 12946413.
- ↑ Busk, P.K. and Møller, B.L. (2002). „Dhurrin synthesis in sorghum is regulated at the transcriptional level and induced by nitrogen fertilization in older plants”. Plant Physiol. 129: 1222-1231. PMID 12114576.
- ↑ Kristensen, C., Morant, M., Olsen, C.E., Ekstrøm, C.T., Galbraith, D.W., Møller, B.L. and Bak, S. (2005). „Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome”. Proc. Natl. Acad. Sci. USA 102: 1779-1784. PMID 15665094.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.