Cefalotin

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Cefalotin
(IUPAC) ime
(6R,7R)-3-[(acetoksi)metil]-8-okso-7-[(2-tienilacetil)amino]-5-tia-1-azabiciklo[4.2.0]okt-2-en-2-karboksilna kiselina
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
MedlinePlus a682860
Identifikatori
CAS broj 153-61-7
ATC kod J01DB03
PubChem[1][2] 6024
DrugBank DB00456
ChemSpider[3] 5802
UNII R72LW146E6 YesY
KEGG[4] D07635 YesY
ChEBI CHEBI:124991 YesY
ChEMBL[5] CHEMBL617 YesY
Hemijski podaci
Formula C16H16N2O6S2 
Mol. masa 396,44 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost n/a
Vezivanje za proteine plazme 65 to 80%
Metabolizam Hepatic
Poluvreme eliminacije 30 minuta do 1 data
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća A(AU)
Pravni status Samo na recept (S4) (AU) POM (UK)
Način primene IV

Cefalotin (INN) je cefalosporinski antibiotik prve generacije. On je bio privi cefalosporin koji je plasiran na trižište (1964). On je i dalje u širokoj upotrebi. Cefalotin se intravenoznol administerira. Njegov antimikrobni spektar je sličan cefazolinu i oralnom agensu cefaleksinu. Cefalotin natrijum je u prodaji pod imenom Keflin.[6][7][8][9]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Singh P, Dimitriou V, Mahajan RP, Crossley AW: Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering. Br J Anaesth. 1993 Nov;71(5):685-8. PMID 8251281
  7. Yost CS: A new look at the respiratory stimulant doxapram. CNS Drug Rev. 2006 Fall-Winter;12(3-4):236-49. PMID 17227289
  8. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  9. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets" 36 (Database issue). pp. D901–6. PMID 18048412. 

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