CENTG1

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Arf-GAP sa GTPazom, ANK ponavljanje i protein 2 sa PH domenom
PDB prikaz baziran na 2bmj.
Dostupne strukture
2BMJ, 2IWR, 2RLO
Identifikatori
Simboli	AGAP2; CENTG1; GGAP2; PIKE
Vanjski ID	OMIM: 605476 HomoloGene: 86815 GeneCards: AGAP2 Gene
Ontologija gena Molekularna funkcija • nucleotidno vezivanje • GTP vezivanje • aktivator dejstva ARF GTPaze • vezivanje zink jona • vezivanje metalnog jona Celularna komponenta • intraćelijski • nukleus • nukleolus • citoplazma • mitohondrija Biološki proces • prenos signala posredovan malom GTPazom • vođenje aksona • proteinski transport • regulacija aktivnosti ARF GTPaze • negativna regulacija proteinskog kataboličkog procesa • negativna regulacija neuronske apoptoze
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	116986	216439
Ensembl	ENSG00000135439	ENSMUSG00000025422
UniProt	Q99490	Q3UHD9
RefSeq (mRNA)	NM_001122772.2	NM_001033263.4
RefSeq (protein)	NP_001116244.1	NP_001028435.1
Lokacija (UCSC)	Chr 12: 58.12 - 58.14 Mb	Chr 10: 126.52 - 126.53 Mb
PubMed pretraga	[1]	[2]

CENTG1 (Arf-GAP sa GTPazom, ANK ponavljanje i protein 2 koji sadrži PH domen) je enzim koji je kod ljudi kodiran AGAP2 genom.

Interakcije

CENTG1 formira interakcije sa PIK3R1, HOMER1 i EPB41L1.

Literatura

• Nagase T, Seki N, Ishikawa K, et al. (1996). „Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.”. DNA Res. 3 (1): 17–24. DOI:10.1093/dnares/3.1.17. PMID 8724849. 
• Elkahloun AG, Krizman DB, Wang Z, et al. (1997). „Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.”. Genomics 42 (2): 295–301. DOI:10.1006/geno.1997.4727. PMID 9192850. 
• Ye K, Hurt KJ, Wu FY, et al. (2001). „Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.”. Cell 103 (6): 919–30. DOI:10.1016/S0092-8674(00)00195-1. PMID 11136977. 
• Ye K, Aghdasi B, Luo HR, et al. (2002). „Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.”. Nature 415 (6871): 541–4. DOI:10.1038/415541a. PMID 11823862. 
• Nie Z, Stanley KT, Stauffer S, et al. (2003). „AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.”. J. Biol. Chem. 277 (50): 48965–75. DOI:10.1074/jbc.M202969200. PMID 12388557. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Xia C, Ma W, Stafford LJ, et al. (2003). „GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.”. Mol. Cell. Biol. 23 (7): 2476–88. DOI:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130. 
• Rong R, Ahn JY, Huang H, et al. (2003). „PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.”. Nat. Neurosci. 6 (11): 1153–61. DOI:10.1038/nn1134. PMID 14528310. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Ahn JY, Rong R, Kroll TG, et al. (2004). „PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.”. J. Biol. Chem. 279 (16): 16441–51. DOI:10.1074/jbc.M312175200. PMID 14761976. 
• Ahn JY, Hu Y, Kroll TG, et al. (2004). „PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.”. Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. DOI:10.1073/pnas.0400921101. PMC 406454. PMID 15118108. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Nie Z, Fei J, Premont RT, Randazzo PA (2005). „The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3.”. J. Cell. Sci. 118 (Pt 15): 3555–66. DOI:10.1242/jcs.02486. PMID 16079295. 
• Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). „Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.”. Neuropathol. Appl. Neurobiol. 31 (5): 486–90. DOI:10.1111/j.1365-2990.2005.00660.x. PMID 16150119. 
• Hu Y, Liu Z, Ye K (2006). „Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.”. Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. DOI:10.1073/pnas.0507365102. PMC 1283830. PMID 16263930. 
• Tang X, Feng Y, Ye K (2007). „Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.”. Cell Death Differ. 14 (2): 368–77. DOI:10.1038/sj.cdd.4402011. PMID 16841086. 
• Soundararajan M, Yang X, Elkins JM, et al. (2007). „The centaurin gamma-1 GTPase-like domain functions as an NTPase.”. Biochem. J. 401 (3): 679–88. DOI:10.1042/BJ20060555. PMC 1770848. PMID 17037982. 
• Werden SJ, Barrett JW, Wang G, et al. (2007). „M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.”. J. Virol. 81 (5): 2340–8. DOI:10.1128/JVI.01310-06. PMC 1865929. PMID 17151107. 
• Liu X, Hu Y, Hao C, et al. (2007). „PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.”. Oncogene 26 (34): 4918–27. DOI:10.1038/sj.onc.1210290. PMID 17297440. 
• Dunphy JL, Ye K, Casanova JE (2007). „Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2.”. Traffic 8 (6): 661–72. DOI:10.1111/j.1600-0854.2007.00561.x. PMID 17461797.