Bifenil 2,3-dioksigenaza
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| Bifenil 2,3-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.18 | ||||||||
| CAS broj | 103289-55-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Bifenil 2,3-dioksigenaza (EC 1.14.12.18, bifenilna dioksigenaza) je enzim sa sistematskim imenom bifenil,NADH:kiseonik oksidoreduktaza (2,3-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- bifenil + NADH + H+ + O2 (1S,2R)-3-fenilcikloheksa-3,5-dien-1,2-diol + NAD+
Ovaj enzim sadrži jon Fe2+. Enzim iz Burkholderia fungorum LB400 je deo multikomponentnog sistema koji se sastoji od NADH:feredoksin oksidoreduktaze (FAD kofaktor), [2Fe-2S] Riskijevog tipa feredoksina, i terminalne oksigenaze koja sadrži [2Fe-2S] Riskijve tip gvožđe-sumpornog klastera i katalitičko mononuklearno gvožđe koje nije vezano za hem.
Reference[uredi | uredi kod]
- ↑ Haddock, J.D. and Gibson, D.T. (1995). „Purification and characterization of the oxygenase component of biphenyl 2,3-dioxygenase from Pseudomonas sp. strain LB400”. J. Bacteriol. 177: 5834-5839. PMID 7592331.
- ↑ Haddock, J.D., Pelletier, D.A. and Gibson, D.T. (1997). „Purification and properties of ferredoxinBPH, a component of biphenyl 2,3-dioxygenase of Pseudomonas sp. strain LB400”. J. Indust. Microbiol. Biotechnol. 19: 355-359. PMID 9451832.
- ↑ Broadus, R.M. and Haddock, J.D. (1998). „Purification and characterization of the NADH:ferredoxinBPH oxidoreductase component of biphenyl 2,3-dioxygenase from Pseudomonas sp. strain LB400”. Arch. Microbiol. 170: 106-112. PMID 9683647.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.