Bifenil-2,3-diol 1,2-dioksigenaza
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Bifenil-2,3-diol 1,2-dioksigenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.13.11.39 | ||||||||
CAS broj | 103679-58-9 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Bifenil-2,3-diol 1,2-dioksigenaza (EC 1.13.11.39, 2,3-dihidroksibifenilna dioksigenaza, bifenil-2,3-diolna dioksigenaza, bphC (gen)) je enzim sa sistematskim imenom bifenil-2,3-diol:kiseonik 1,2-oksidoreduktaza (deciklizacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- bifenil-2,3-diol + O2 2-hidroksi-6-okso-6-fenilheksa-2,4-dienoat
Ovaj enzim sadrži Fe2+ ili Mn2+. On učestvuje u degradaciji bifenila i PCB (poli hlorinatih bifenila)
Reference[uredi | uredi kod]
- ↑ Eltis, L.D., Hofmann, B., Hecht, H.J., Lunsdorf, H. and Timmis, K.N. (1993). „Purification and crystallization of 2,3-dihydroxybiphenyl 1,2-dioxygenase”. J. Biol. Chem. 268: 2727-2732. PMID 8428946.
- ↑ Uragami, Y., Senda, T., Sugimoto, K., Sato, N., Nagarajan, V., Masai, E., Fukuda, M. and Mitsu, Y. (2001). „Crystal structures of substrate free and complex forms of reactivated BphC, an extradiol type ring-cleavage dioxygenase”. J. Inorg. Biochem. 83: 269-279. PMID 11293547.
- ↑ Hatta, T., Mukerjee-Dhar, G., Damborsky, J., Kiyohara, H. and Kimbara, K. (2003). „Characterization of a novel thermostable Mn(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase from a polychlorinated biphenyl- and naphthalene-degrading Bacillus sp. JF8”. J. Biol. Chem. 278: 21483-21492. PMID 12672826.
- ↑ Wesche, J., Hammer, E., Becher, D., Burchhardt, G. and Schauer, F. (2005). „The bphC gene-encoded 2,3-dihydroxybiphenyl-1,2-dioxygenase is involved in complete degradation of dibenzofuran by the biphenyl-degrading bacterium Ralstonia sp. SBUG 290”. J. Appl. Microbiol. 98: 635-645. PMID 15715866.
- ↑ Iwata, K., Nojiri, H., Shimizu, K., Yoshida, T., Habe, H. and Omori, T. (2003). „Expression, purification, and characterization of 2′-aminobiphenyl-2,3-diol 1,2-dioxygenase from carbazole-degrader Pseudomonas resinovorans strain CA10”. Biosci. Biotechnol. Biochem. 67: 300-307. PMID 12728990.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.