B-adrenergički-receptor kinaza
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| B-adrenergički-receptor kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.15 | ||||||||
| CAS broj | 102925-39-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
B-adrenergički-receptor kinaza (EC 2.7.11.15, ATP:beta-adrenergički-receptor fosfotransferaza, beta-adrenergički receptor-specifična kinaza, beta-AR kinaza, beta-ARK, beta-ARK 1, beta-ARK 2, beta-receptor kinaza, GRK2, GRK3, beta-adrenergički-receptor kinaza (fosforilacija), beta2ARK, betaARK1, beta-adrenoceptor kinaza, beta-adrenoceptor kinaza 1, beta-adrenoceptor kinaza 2, ADRBK1, BARK1, adrenergički receptor kinaza, STK15) je enzim sa sistematskim imenom ATP:(beta-adrenergic receptor) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).
Reference[uredi | uredi kod]
- ↑ Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J. and Caron, M.G. (1987). „Purification and characterization of the β-adrenergic receptor kinase”. J. Biol. Chem. 262: 9026-9032. PMID 3036840.
- ↑ Kim, C.M., Dion, S.B., Onorato, J.J. and Benovic, J.L. (1993). „Expression and characterization of two β-adrenergic receptor kinase isoforms using the baculovirus expression system”. Receptor 3: 39-55. PMID 8394172.
- ↑ Laugwitz, K.L., Kronsbein, K., Schmitt, M., Hoffmann, K., Seyfarth, M., Schomig, A. and Ungerer, M. (1997). „Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes”. Cardiovasc Res 35: 324-333. PMID 9349395.
- ↑ Ferguson, S.S., Menard, L., Barak, L.S., Koch, W.J., Colapietro, A.M. and Caron, M.G. (1995). „Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by betaARK1”. J. Biol. Chem. 270: 24782-24789. PMID 7559596.
- ↑ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626-633. PMID 14654303.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.