Azotsuboksid reduktaza (NAD(P), formira azot monoksid)
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| Azotsuboksid reduktaza (NAD(P), formira azot monoksid) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.1.14 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Azotsuboksid reduktaza (NAD(P), formira azot monoksid) (EC 1.7.1.14, fungalna azotno suboksidna reduktaza, citohrom P450nor, NOR (nespecifična)) je enzim sa sistematskim imenom azot monoksid:NAD(P) oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N2O + NAD(P)+ +H2O 2 NO + NAD(P)H + H+
Ovaj enzim je hem-tiolatni protein (P450). Enzim iz Fusarium oksisporum koristi samo NADH, dok izozim iz Trichosporon cutaneum koristi NADH i NADPH.
Reference[uredi | uredi kod]
- ↑ Shoun, H. and Tanimoto, T. (1991). „Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction”. J. Biol. Chem. 266: 11078-11082. PMID 2040619.
- ↑ Shiro, Y., Fujii, M., Iizuka, T., Adachi, S., Tsukamoto, K., Nakahara, K. and Shoun, H. (1995). „Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism”. J. Biol. Chem. 270: 1617-1623. PMID 7829493.
- ↑ Zhang, L., Kudo, T., Takaya, N. and Shoun, H. (2002). „The B′ helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH”. J. Biol. Chem. 277: 33842-33847. PMID 12105197.
- ↑ Oshima, R., Fushinobu, S., Su, F., Zhang, L., Takaya, N. and Shoun, H. (2004). „Structural evidence for direct hydride transfer from NADH to cytochrome P450nor”. J. Mol. Biol. 342: 207-217. PMID 15313618.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.