Aureuzidin sintaza
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| Aureuzidin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.21.3.6 | ||||||||
| CAS broj | 320784-48-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aureuzidin sintaza (EC 1.21.3.6, AmAS1) je enzim sa sistematskim imenom 2',4,4',6'-tetrahidroksihalkon 4'-O-beta-D-glukozid:kiseonik oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 2',4,4',6'-tetrahidroksihalkon 4'-O-beta-D-glukozid + O2 aureuzidin 6-O-beta-D-glukozid + H2O
- (2) 2',3,4,4',6'-pentahidroksihalkon 4'-O-beta-D-glukozid + 1/2 O2 aureuzidin 6-O-beta-D-glukozid + H2O
- (3) 2',3,4,4',6'-pentahidroksihalkon 4'-O-beta-D-glukozid + O2 brakteatin 6-O-beta-D-glukozid + H2O
Ovaj glikoprotein sadrži bakar. On je prisutan u cveću žute boje kao što je Antirrhinum majus.
Reference[uredi | uredi kod]
- ↑ Nakayama, T., Yonekura-Sakakibara, K., Sato, T., Kikuchi, S., Fukui, Y., Fukuchi-Mizutani, M., Ueda, T., Nakao, M., Tanaka, Y., Kusumi, T. and Nishino, T. (2000). „Aureusidin synthase: A polyphenol oxidase homolog responsible for flower coloration”. Science 290: 1163-1166. PMID 11073455.
- ↑ Nakayama, T., Sato, T., Fukui, Y., Yonekura-Sakakibara, K., Hayashi, H., Tanaka, Y., Kusumi, T. and Nishino, T. (2001). „Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration”. FEBS Lett. 499: 107-111. PMID 11418122.
- ↑ Sato, T., Nakayama, T., Kikuchi, S., Fukui, Y., Yonekura-Sakakibara, K., Ueda, T., Nishino, T., Tanaka, Y. and Kusumi, T. (2001). „Enzymatic formation of aurones in the extracts of yellow snapdragon flowers”. Plant Sci. 160: 229-236. PMID 11164594.
- ↑ Ono, E., Fukuchi-Mizutani, M., Nakamura, N., Fukui, Y., Yonekura-Sakakibara, K., Yamaguchi, M., Nakayama, T., Tanaka, T., Kusumi, T. and Tanaka, Y. (2006). „Yellow flowers generated by expression of the aurone biosynthetic pathway”. Proc. Natl. Acad. Sci. USA 103: 11075-11080. PMID 16832053.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.