Atrolizin-A
(Preusmjereno sa stranice Atrolizin A)
| Atrolizin-A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.1 | ||||||||
| CAS broj | 37288-82-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Atrolizin-A (EC 3.4.24.1, Crotalus atrox metaloendopeptidaza a, hemoragijski toksin a, Crotalus atrox alfa-proteinaza, Crotalus atrox proteinaza, botropajin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje Asn3-Gln, His5-Leu, His10-Leu, Ala14-Leu i Tyr16-Leu u insulinskom B lancu. Uklanjanje C-terminalnog Leu sa malih peptida
Ova hemoragijska endopeptidaza je jedna od šest hemoragijskih toksina u venomu zvečarke Crotalus atrox.
Reference[uredi | uredi kod]
- ↑ Bjarnason, J.B. and Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry 17: 3395-3404. PMID 210790.
- ↑ Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). „Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom”. Arch. Biochem. Biophys. 253: 108-121. PMID 2949699.
- ↑ Bjarnason, J.B., Hamilton, D. and Fox, J.W. (1988). „Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom”. Biol. Chem. Hoppe-Seyler 369: 121-129. PMID 3060135.
- ↑ Bjarnason, J.B. and Fox, J.W. (1989). „Hemorrhagic toxins from snake venoms”. J. Toxicol. Toxin Rev. 7: 121-209.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.