Aspartat dehidrogenaza
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| Aspartat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.1.21 | ||||||||
| CAS broj | 37278-97-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aspartat dehidrogenaza (EC 1.4.1.21, NAD-zavisna aspartatna dehidrogenaza, NADH2-zavisna aspartatna dehidrogenaza, NADP+-zavisna aspartatna dehidrogenaza) je enzim sa sistematskim imenom L-aspartat:NAD(P)+ oksidoreduktaza (deaminacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-aspartat +H2O + NAD(P)+ oksaloacetat + NH3 + NAD(P)H + H+
Ovaj enzim je striktno specifičan za L-aspartat kao supstrat. On katalizuje prvi korak u NAD biosinteza iz aspartata. Enzim ima veći afinitet za NAD+ od NADP+.
Reference[uredi | uredi kod]
- ↑ Yang, Z., Savchenko, A., Yakunin, A., Zhang, R., Edwards, A., Arrowsmith, C. and Tong, L. (2003). „Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.”. J. Biol. Chem. 278: 8804-8808. PMID 12496312.
- ↑ Okamura, T., Noda, H., Fukuda, S. and Ohsugi, M. (1998). „Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541”. J. Nutr. Sci. Vitaminol. 44: 483-490. PMID 9819709.
- ↑ Kretovich, W.L., Kariakina, T.I., Weinova, M.K., Sidelnikova, L.I. and Kazakova, O.W. (1981). „The synthesis of aspartic acid in Rhizobium lupini bacteroids”. Plant Soil 61: 145-156.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.