Arahidonatna 12-lipoksigenaza
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| Arahidonatna 12-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.31 | ||||||||
| CAS broj | 82391-43-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Arahidonatna 12-lipoksigenaza (EC 1.13.11.31, Delta12-lipoksigenaza, 12-lipoksigenaza, 12Delta-lipoksigenaza, C-12 lipoksigenaza, 12S-lipoksigenaza, leukotrienska A4 sintaza, LTA4 sintaza) je enzim sa sistematskim imenom arahidonat:kiseonik 12-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- arahidonat + O2 (5Z,8Z,10E,14Z)-(12S)-12-hidroperoksiikosa-5,8,10,14-tetraenoat
Produkt se brzo redukuje do korespondirajućeg 12S-hidroksi jedinjenja.
Reference[uredi | uredi kod]
- ↑ Hamberg, M. and Samuelsson, B. (1974). „Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets”. Proc. Natl. Acad. Sci. USA 71: 3400-3404. PMID 4215079.
- ↑ Nugteren, D.H. (1975). „Arachidonate lipoxygenase in blood platelets”. Biochim. Biophys. Acta 380: 299-307. PMID 804329.
- ↑ Wallach, D.P. and Brown, V.R. (1981). „A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases”. Biochim. Biophys. Acta 663: 361-372. PMID 6783111.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.