Amorpha-4,11-dienska sintaza
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| Amorpha-4,11-dienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.24 | ||||||||
| CAS broj | 259213-60-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Amorpha-4,11-dienska sintaza (EC 4.2.3.24, amorfadienska sintaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira amorfa-4,11-dien).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat amorfa-4,11-dien + difosfat
Za dejstvo ovog enzima su neophodni joni Mg2+ i Mn2+.
Reference[uredi | uredi kod]
- ↑ Wallaart, T.E., Bouwmeester, H.J., Hille, J., Poppinga, L. and Maijers, N.C. (2001). „Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin”. Planta 212: 460-465. PMID 11289612.
- ↑ Mercke, P., Bengtsson, M., Bouwmeester, H.J., Posthumus, M.A. and Brodelius, P.E. (2000). „Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L”. Arch. Biochem. Biophys. 381: 173-180. PMID 11032404.
- ↑ Bouwmeester, H.J., Wallaart, T.E., Janssen, M.H., van Loo, B., Jansen, B.J., Posthumus, M.A., Schmidt, C.O., De Kraker, J.W., König, W.A. and Franssen, M.C. (1999). „Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis”. Phytochemistry 52: 843-854. PMID 10626375.
- ↑ Chang, Y.J., Song, S.H., Park, S.H. and Kim, S.U. (2000). „Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis”. Arch. Biochem. Biophys. 383: 178-184. PMID 11185551.
- ↑ Martin, V.J., Pitera, D.J., Withers, S.T., Newman, J.D. and Keasling, J.D. (2003). „Engineering a mevalonate pathway in Escherichia coli for production of terpenoids”. Nat. Biotechnol. 21: 796-802. PMID 12778056.
- ↑ Picaud, S., Mercke, P., He, X., Sterner, O., Brodelius, M., Cane, D.E. and Brodelius, P.E. (2006). „Amorpha-4,11-diene synthase: Mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate”. Arch. Biochem. Biophys. 448: 150-155. PMID 16143293.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.