Aminometiltransferaza

Iz Wikipedije, slobodne enciklopedije
Aminometiltransferaza
Identifikatori
EC broj 2.1.2.10
CAS broj 37257-08-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Ontologija gena AmiGO / EGO
Aminometiltransferaza
AMT-Aminomethiltransferase.jpg
Kristalna struktura ljudskog AMT.[1]
Identifikatori
Simbol AMT
Entrez 275
Hugo AMT 473 AMT
OMIM 238310
PDB 1WSR
RefSek NM_000481
UniProt P48728
Drugi podaci
EC broj 2.1.2.10
Lokus Hrom. 3 p21.2-21.1

Aminometiltransferaza (EC 2.1.2.10, S-aminometildihidrolipoilprotein:(6S)-tetrahidrofolat aminometiltransferaza (formira amonijak), T-protein, glicinska sintaza, tetrahidrofolatna aminometiltransferaza, (protein)-8-S-aminometildihidrolipoillizin:tetrahidrofolat aminometiltransferaza (formira amonijak)) je enzim sa sistematskim imenom (protein)-S8-aminometildihidrolipoillizin:tetrahidrofolat aminometiltransferaza (formira amonijak).[2][3][4] Aminometiltransferaza kataboliše formiranje metilentetrahidrofolata. Ona je deo kompleksa glicin dekarboksilaze.

[protein]-S8-aminometildihidrolipoilizin + tetrahidrofolat [protein]-dihidrolipoilizin + 5,10-metilintetrahidrofolat + NH3

Reference[uredi - уреди | uredi izvor]

  1. PDB 1WSR; Okamura-Ikeda K, Hosaka H, Yoshimura M, Yamashita E, Toma S, Nakagawa A, Fujiwara K, Motokawa Y, Taniguchi H (September 2005). "Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia". Journal of Molecular Biology 351 (5): 1146–59. doi:10.1016/j.jmb.2005.06.056. PMID 16051266. 
  2. Okamura-Ikeda, J., Fujiwara, K. and Motokawa, Y. (1982). "Purification and characterization of chicken liver T protein, a component of the glycine cleavage system". J. Biol. Chem. 257: 135–139. PMID 7053363. 
  3. Perham, R.N. (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions". Annu. Rev. Biochem. 69: 961–1004. PMID 10966480. 
  4. Nesbitt, N.M., Baleanu-Gogonea, C., Cicchillo, R.M., Goodson, K., Iwig, D.F., Broadwater, J.A., Haas, J.A., Fox, B.G. and Booker, S.J. (2005). "Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase". Protein Expr. Purif. 39: 269–282. PMID 15642479. 

Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]

<!-{Metiltransferaze}->