Aminoglikozid N6'-acetiltransferaza
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| Aminoglikozid N6'-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.82 | ||||||||
| CAS broj | 56467-65-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aminoglikozid N6'-acetiltransferaza (EC 2.3.1.82, aminoglikozidna 6'-N-acetiltransferaza, aminoglikozid-6'-acetiltransferaza, aminoglikozid-6-N-acetiltransferaza, kanamicinska acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:kanamicin-B N6'-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + kanamicin-B KoA + N6'-acetilkanamicin-B
Antibiotici kanamicin A, kanamicin B, neomicin, [gentamicin]] C1a, gentamicin C2 i sisomicin su supstrati. Antibiotici gentamicin, tobramicin i neomicin, takođe mogu da deluju kao akceptori. 6-amino grupa purpurosaminskog prstena se acetiluje.
Reference[uredi | uredi kod]
- ↑ le Goffic, F. and Martel, A. (1974). „La résistance aux aminosides provoquée par une isoenzyme la kanamycine acétyltransférase”. Biochimie 56: 893-897. PMID 4614862.
- ↑ Benveniste, R. and Davies, J.E. (1971). „Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor”. Biochemistry 10: 1787-1796. PMID 4935296.
- ↑ Dowding, J.E. (1977). „Mechanisms of gentamicin resistance in Staphylococcus aureus'”. Antimicrob. Agents Chemother. 11: 47-50. PMID 836013.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.