C3/C5 konvertaza alternativno komplementnog puta
(Preusmjereno sa stranice Alternativni komplementni put C3/C5 konvertaza)
| C3/C5 konvertaza alternativno komplementnog puta | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.47 | ||||||||
| CAS broj | 80295-67-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
C3/C5 konvertaza alternativno komplementnog puta (EC 3.4.21.47, komplementna komponenta C3/C5 konvertaza (alternativna), proenzimski faktor B, properdinski faktor B, C3 proaktivator, glicinom bogati beta-glikoprotein, toplotno-labilni faktor, C3 konvertaza, C3b,Bb,CVF,Bb,C5 konvertaza, (C3b)n,Bb, komplement C 3(C 5) konvertaza (amplifikacija), konvertaza alternativnog komplementnog puta C3(C5), C5 konvertaza, CVF,Bb, (CVF)-zavisni glicinom-bogati-beta-glukoprotein, C3 konvertaza zavisna od faktora kobrinog venuma) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Arg-Ser veze u alfa-lancu komplementne komponente C3 čime se formira C3a i C3b, i Arg- veze u alfa-lancu komplementne komponente C5 čime se formira C5a i C5b
Ovaj enzim je bimolekulski kompleks komplementnog fragmenta Bb sa bilo C3b ili faktorom kobrinog venuma.
Reference[uredi | uredi kod]
- ↑ Kerr, M.A. (1981). „Human factor B”. Methods Enzymol. 80: 102-112. PMID 7043188.
- ↑ Morley, B.J. and Campbell, R.D. (1984). „Internal homologies of the Ba fragment from human complement component Factor B, as a class III MHC antigen”. EMBO J. 3: 153-157. PMID 6323161.
- ↑ Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321-347. PMID 3052276.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.