Aldehid oksidaza
| Aldehid oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Aldehid oksidaza homodimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.2.3.1 | ||||||||
| CAS broj | 2604002 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aldehid oksidaza (EC 1.2.3.1, hinolinska oksidaza, retinalna oksidaza) je enzim sa sistematskim imenom aldehid:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- aldehid + H2O + O2 karboksilat +H2O2
Ovaj enzim sadrži molibden, [2Fe-2S] centar i FAD. Enzim iz jetre ispoljava široku supstratnu specifičnost i učestvuje u metabolizmu ksenobiotika, uključujući oksidaciju N-heterocikličnih jedinjenja i aldehida i u redukciji N-oksida, nitrozamina, hidroksaminskih kiselina, azo boja, nitropolicikličnih aromatičnih ugljovodonika i sulfoksida. Ovaj enzim je takođe odgovoran za oksidaciju retinala, aktivnist koja je inicijalno bila pripisivana enzimu EC 1.2.3.11, retinalnoj oksidazi.
- ↑ Gordon, A.H., Green, D.E. and Subrahmanyan, V. (1940). „Liver aldehyde oxidase”. Biochem. J. 34: 764-774. PMID 16747217.
- ↑ Knox, W.E. (1946). „The quinine-oxidizing enzyme and liver aldehyde oxidase”. J. Biol. Chem. 163: 699-711. PMID 20985642.
- ↑ Mahler, H.R., Mackler, B., Green, D.E. and Bock, R.M. (1954). „Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein”. J. Biol. Chem. 210: 465-480. PMID 13201608.
- ↑ Krenitsky, T.A., Neil, S.M., Elion, G.B. and Hitchings, G.H. (1972). „A comparison of the specificities of xanthine oxidase and aldehyde oxidase”. Arch. Biochem. Biophys. 150: 585-599. PMID 5044040.
- ↑ Tomita, S., Tsujita, M. and Ichikawa, Y. (1993). „Retinal oxidase is identical to aldehyde oxidase”. FEBS Lett. 336: 272-274. PMID 8262244.
- ↑ Yoshihara, S. and Tatsumi, K. (1997). „Purification and characterization of hepatic aldehyde oxidase in male and female mice”. Arch. Biochem. Biophys. 338: 29-34. PMID 9015384.
- ↑ Huang, D.-Y., Furukawa, A. and Ichikawa, Y. (1999). „Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli”. Arch. Biochem. Biophys. 364: 264-272. PMID 10190983.
- ↑ Uchida, H., Kondo, D., Yamashita, A., Nagaosa, Y., Sakurai, T., Fujii, Y., Fujishiro, K., Aisaka, K. and Uwajima, T. (2003). „Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690”. FEMS Microbiol. Lett. 229: 31-36. PMID 14659539.
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