Adrenodoksin-NADP+ reduktaza

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Adrenodoksin-NADP+ reduktaza
Identifikatori
EC broj 1.18.1.6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Adrenodoksin-NADP+ reduktaza (EC 1.18.1.6, adrenodoksinska reduktaza, nikotinamid adenin dinukleotid fosfat-adrenodoksinska reduktaza, AdR, NADPH:adrenal feredoksin oksidoreduktaza) je enzim sa sistematskim imenom adrendoksin:NADP+ oksidoreduktaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 redukovani adrenodoksin + NADP+ 2 oksidovani adrenodoksin + NADPH + H+

Ovaj enzim je flavoprotein (FAD). On je prva komponenta mitohondrijskog citohroma P-450 sistema transfera elektrona. Ovaj enzim učestvuje u biosintezi steroidnih hormona.

Reference[uredi | uredi kod]

  1. Omura, T., Sanders, E., Estabrook, R.W., Cooper, D.Y. and Rosenthal, O. (1966). „Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase”. Arch. Biochem. Biophys. 117: 660-673. 
  2. Chu, J.W. and Kimura, T. (1973). „Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein)”. J. Biol. Chem. 248: 2089-2094. PMID 4144106. 
  3. Sugiyama, T. and Yamano, T. (1975). „Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria”. FEBS Lett 52: 145-148. PMID 235468. 
  4. Hanukoglu, I. and Jefcoate, C.R. (1980). „Mitochondrial cytochrome P-450sec. Mechanism of electron transport by adrenodoxin”. J. Biol. Chem. 255: 3057-3061. PMID 6766943. 
  5. Hanukoglu, I. and Hanukoglu, Z. (1986). „Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation”. Eur. J. Biochem. 157: 27-31. PMID 3011431. 
  6. Hanukoglu, I. and Gutfinger, T. (1989). „cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases”. Eur. J. Biochem. 180: 479-484. PMID 2924777. 
  7. Ziegler, G.A., Vonrhein, C., Hanukoglu, I. and Schulz, G.E. (1999). „The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis”. J. Mol. Biol. 289: 981-990. PMID 10369776. 

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