Aciloksiacilna hidrolaza
(Preusmjereno sa stranice Aciloksiacil hidrolaza)
| Aciloksiacilna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Aciloksiacilna hidrolaza heterodimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.1.1.77 | ||||||||
| CAS broj | 110277-64-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aciloksiacilna hidrolaza (EC 3.1.1.77) je enzim sa sistematskim imenom '.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-(aciloksi)acil grupa bakterijskog toksina + H2O 3-hidroksiacil grupa bakterijskog toksina + masna kiselina
Supstrat je lipid A na redukujućem kraju toksičnog lipopolisaharida (LPS) u bakteriji Salmonella typhimurium i srodnim organizmima.
Reference[uredi | uredi kod]
- ↑ Erwin, A.L. and Munford, R.S. (1990). „Deacylation of structurally diverse lipopolysaccharides by human acyloxyacyl hydrolase”. J. Biol. Chem. 265: 16444-16449. PMID 2398058.
- ↑ Hagen, F.S., Grant, F.J., Kuijper, J.L., Slaughter, C.A., Moomaw, C.R., Orth, K., O'Hara, P.J. and Munford, R.S. (1991). „Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides”. Biochemistry 30: 8415-8423. PMID 1883828.
- ↑ Munford, R.S. and Hunter, J.P. (1992). „Acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides, has phospholipase, lysophospholipase, diacylglycerollipase, and acyltransferase activities in vitro”. J. Biol. Chem. 267: 10116-10121. PMID 1577781.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.