Acetolaktat sintaza
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| Acetolaktat sintaza | |||||||||
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| Acetolaktat sintaza tetramer, Bacillus subtilis | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.2.1.6 | ||||||||
| CAS broj | 9027-45-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Acetolaktat sintaza (EC 2.2.1.6, alfa-acetohidroksi kiselinska sintetaza, alfa-acetohidroksikiselinska sintaza, alfa-acetolaktatna sintaza, alfa-acetolaktatna sintetaza, acetohidroksi kiselinska sintetaza, acetohidroksikiselinska sintaza, acetolaktat piruvat-lijaza (karboksilacija), acetomlečna sintetaza) je enzim sa sistematskim imenom piruvat:piruvat acetaldehidtransferaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 piruvat 2-acetolaktat + CO2
Za rad ovog enzima je neophodan tiamin difosfat. Prikazana reakcija je deo biosinteze valina. Ovaj enzim takođe može da vrši transfer acetaldehida sa piruvata na 2-oksobutanoata, čime se formira 2-etil-2-hidroksi-3-oksobutanoat, takođe poznat kao 2-aceto-2-hidroksibutanoat.
Reference[uredi - уреди | uredi kôd]
- ↑ Bauerle, R.H., Freundlich, M., Størmer, F.C. and Umbarger, H.E. (1964). „Control of isoleucine, valine and leucine biosynthesis. II. Endproduct inhibition by valine of acetohydroxy acid synthetase in Salmonella typhimurium”. Biochim. Biophys. Acta 92: 142-149. PMID 14243762.
- ↑ Huseby, N.E., Christensen, T.B., Olsen, B.R. and Størmer, F.C. (1971). „The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Subunit structure”. Eur. J. Biochem. 20: 209-214. PMID 5560406.
- ↑ Størmer, F.C., Solberg, Y. and Hovig, T. (1969). „The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties”. Eur. J. Biochem. 10: 251-260. PMID 5823101.
- ↑ Barak, Z., Chipman, D.M. and Gollop, N. (1987). „Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria”. J. Bacteriol. 169: 3750-3756. PMID 3301814.
Literatura[uredi - уреди | uredi kôd]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.
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