Acetaldehid dehidrogenaza (acetilacija)
(Preusmjereno sa stranice Acetaldehidna dehidrogenaza)
| Acetaldehid dehidrogenaza (acetilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Acetaldehid dehidrogenaza (1NVM) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.2.1.10 | ||||||||
| CAS broj | 9028-91-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acetaldehid dehidrogenaza (acetilacija) (EC 1.2.1.10, aldehidna dehidrogenaza (acilacija), ADA, acilirajuća acetaldehidna dehidrogenaza, DmpF) je enzim sa sistematskim imenom acetaldehid:NAD+ oksidoreduktaza (KoA-acetilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetaldehid + KoA + NAD+ acetil-KoA + NADH + H+
Ovaj enzim takođe deluje, mada sporije, na glikolaldehid, propanal i butanal. Kod Pseudomonas species, on formira deo bifunkcionalanog enzima sa EC 4.1.3.39, 4-hidroksi-2-oksovaleratnom aldolazom. To je finalni enzim u putu meta-cepanja za degradaciju fenola, metilfenola i katehola, koji konvertuje acetaldehid proizveden posredstvom EC 4.1.3.39 u acetil-KoA. NADP+ može da zameni NAD+ ali je brzina reakcije znatno niža.
Reference[uredi | uredi kod]
- ↑ Burton, R.M. and Stadtman, E.R. (1953). „The oxidation of acetaldehyde to acetyl coenzyme A”. J. Biol. Chem. 202: 873-890. PMID 13061511.
- ↑ Smith, L.T. and Kaplan, N.O. (1980). „Purification, properties, and kinetic mechanism of coenzyme A-linked aldehyde dehydrogenase from Clostridium kluyveri”. Arch. Biochem. Biophys. 203: 663-675. PMID 7458347.
- ↑ Powlowski, J., Sahlman, L. and Shingler, V. (1993). „Purification and properties of the physically associated meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600”. J. Bacteriol. 175: 377-385. PMID 8419288.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.