Abietadienol hidroksilaza
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| Abietadienol hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.109 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Abietadienol hidroksilaza (EC 1.14.13.109, CYP720B1, PtAO, abietadienolna hidroksilaza (nespecifična)) je enzim sa sistematskim imenom abieta-7,13-dien-18-ol,NADPH:kiseonik oksidoreduktaza (18-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- abieta-7,13-dien-18-ol + NADPH + H+ + O2 abieta-7,13-dien-18-al + NADP+ + 2H2O (sveukupna reakcija)
- (1a) abieta-7,13-dien-18-ol + NADPH + H+ + O2 abieta-7,13-dien-18,18-diol + NADP+ + H2O
- (1b) abieta-7,13-dien-18,18-diol abieta-7,13-dien-18-al + H2O (spontana reakcija)
Ovaj enzim je hem-tiolatni protein (P-450). On učestvuje u biosintezi abietinske kiseline.
Reference[uredi | uredi kod]
- ↑ Funk, C. and Croteau, R. (1994). „Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis”. Arch. Biochem. Biophys. 308: 258-266. PMID 8311462.
- ↑ Funk, C., Lewinsohn, E., Vogel, B.S., Steele, C.L. and Croteau, R. (1994). „Regulation of oleoresinosis in grand fir (Abies grandis) (coordinate induction of monoterpene and diterpene cyclases and two cytochrome P450-dependent diterpenoid hydroxylases by stem wounding)”. Plant Physiol. 106: 999-1005. PMID 12232380.
- ↑ Ro, D.K., Arimura, G., Lau, S.Y., Piers, E. and Bohlmann, J. (2005). „Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase”. Proc. Natl. Acad. Sci. USA 102: 8060-8065. PMID 15911762.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.