Alfa-2B adrenergički receptor
(Preusmjereno sa stranice ADRA2B)
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| Adrenergički alfa-2B receptor | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | ADRA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR | ||||||||||
| Vanjski ID | OMIM: 104260 MGI: 87935 HomoloGene: 553 IUPHAR: α2B-adrenoceptor GeneCards: ADRA2B Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 151 | 11552 | |||||||||
| Ensembl | n/a | ENSMUSG00000058620 | |||||||||
| UniProt | P18089 | P30545 | |||||||||
| RefSeq (mRNA) | NM_000682 | NM_009633 | |||||||||
| RefSeq (protein) | NP_000673 | NP_033763 | |||||||||
| Lokacija (UCSC) | n/a | Chr 2: 127.05 - 127.06 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Alfa-2B adrenergički receptor (α2B adrenoceptor) je G-protein spregnuti receptor. On je tip adrenergičke receptorske familije. Humani gen koji kodira ovaj receptor ima simbol ADRA2B.[1] ADRA2B ortolozi[2] su identifikovani kod nekoliko sisara.
Receptor[uredi | uredi kod]
Postoje tri visoko homologna tipa alfa-2-adrenergičkog receptora: alfa2A, alfa2B, i alfa2C. Ti receptori učestvuju u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema.
Gen[uredi | uredi kod]
Ovaj gen kodira alfa2B tip receptora. On se vezuje za eIF-2B, faktor razmene guanin nukleotida koji učestvuje u regulaciji translacije. Za polimorfnu varijantu alfa2B tip, kojoj nedostaju 3 glutaminske kiseline iz elementa ponavljanja glutaminskih kiselina, je ustanoljeno da ima umanjenu GPCR kinazama-posredovanu fosforilaciju i desenzitizaciju. Ova polimorfna forma je isto tako povezana sa umanjenom bazalnim metabolizmom kod gojaznih osoba i moguće je da doprinosi patogenezi gojaznosti. Ovaj gen ne sadrži introne.[1]
Selektivni ligandi[uredi | uredi kod]
Antagonisti[uredi | uredi kod]
Vidi još[uredi | uredi kod]
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Lomasney JW, Lorenz W, Allen LF, et al. (1990). „Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.”. Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094–8. DOI:10.1073/pnas.87.13.5094. PMC 54268. PMID 2164221.
- McClue SJ, Milligan G (1990). „The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.”. FEBS Lett. 269 (2): 430–4. DOI:10.1016/0014-5793(90)81209-7. PMID 2169434.
- Weinshank RL, Zgombick JM, Macchi M, et al. (1990). „Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.”. Mol. Pharmacol. 38 (5): 681–8. PMID 2172775.
- Chang AC, Ho TF, Chang NC (1990). „In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.”. Biochem. Biophys. Res. Commun. 172 (2): 817–23. DOI:10.1016/0006-291X(90)90748-C. PMID 2173582.
- Regan JW, Kobilka TS, Yang-Feng TL, et al. (1988). „Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.”. Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. DOI:10.1073/pnas.85.17.6301. PMC 281957. PMID 2842764.
- Petrash AC, Bylund DB (1986). „Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain.”. Life Sci. 38 (23): 2129–37. DOI:10.1016/0024-3205(86)90212-2. PMID 3012234.
- Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). „A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.”. J. Biol. Chem. 272 (31): 19099–102. DOI:10.1074/jbc.272.31.19099. PMID 9235896.
- Okusa MD, Huang L, Momose-Hotokezaka A, et al. (1998). „Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.”. Am. J. Physiol. 273 (6 Pt 2): F883–91. PMID 9435676.
- Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). „The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.”. J. Biol. Chem. 274 (19): 13462–9. DOI:10.1074/jbc.274.19.13462. PMID 10224112.
- Heinonen P, Koulu M, Pesonen U, et al. (1999). „Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.”. J. Clin. Endocrinol. Metab. 84 (7): 2429–33. DOI:10.1210/jc.84.7.2429. PMID 10404816.
- Hein L, Altman JD, Kobilka BK (2000). „Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.”. Nature 402 (6758): 181–4. DOI:10.1038/46040. PMID 10647009.
- Small KM, Brown KM, Forbes SL, Liggett SB (2001). „Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.”. J. Biol. Chem. 276 (7): 4917–22. DOI:10.1074/jbc.M008118200. PMID 11056163.
- Snapir A, Mikkelsson J, Perola M, et al. (2003). „Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.”. J. Am. Coll. Cardiol. 41 (2): 190–4. DOI:10.1016/S0735-1097(02)02702-X. PMID 12535806.
- Sykiotis GP, Polyzogopoulou E, Georgopoulos NA, et al. (2004). „The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.”. Clin. Auton. Res. 13 (3): 203–7. DOI:10.1007/s10286-003-0087-5. PMID 12822042.
- Chotani MA, Mitra S, Su BY, et al. (2004). „Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.”. Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. DOI:10.1152/ajpheart.00268.2003. PMID 12946937.
- Von Wowern F, Bengtsson K, Lindblad U, et al. (2004). „Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.”. Hypertension 43 (3): 592–7. DOI:10.1161/01.HYP.0000116224.51189.80. PMID 14744925.
- Cayla C, Heinonen P, Viikari L, et al. (2004). „Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.”. Biochem. Pharmacol. 67 (3): 469–78. DOI:10.1016/j.bcp.2003.09.029. PMID 15037199.
- Phares DA, Halverstadt AA, Shuldiner AR, et al. (2004). „Association between body fat response to exercise training and multilocus ADR genotypes.”. Obes. Res. 12 (5): 807–15. DOI:10.1038/oby.2004.97. PMID 15166301.
- Siitonen N, Lindström J, Eriksson J, et al. (2005). „Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.”. Diabetologia 47 (8): 1416–24. DOI:10.1007/s00125-004-1462-z. PMID 15309292.
- Belfer I, Buzas B, Hipp H, et al. (2005). „Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.”. J. Hum. Genet. 50 (1): 12–20. DOI:10.1007/s10038-004-0211-y. PMID 15592690.
Spoljašnje veze[uredi | uredi kod]
- „α2B-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-05.