ADP-zavisna kratkolančana-acil-KoA hidrolaza
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| ADP-zavisna kratkolančana-acil-KoA hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.2.18 | ||||||||
| CAS broj | 117698-16-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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ADP-zavisna kratkolančana-acil-KoA hidrolaza (EC 3.1.2.18, kratkolančana acil koenzim A hidrolaza, propionil koenzim A hidrolaza, propionil-KoA hidrolaza, propionil-KoA tioesteraza, kratkolančana acil-KoA hidrolaza, kratkolančana acil-KoA tioesteraza) je enzim sa sistematskim imenom ADP-zavisna-kratkolančana-acil-KoA hidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + H2O KoA + karboksilat
Za dejstvo ovog enzima je neophodan ADP. NADH deluje kao inhibitor. Enzim ima maksimalno dejstvo sa propanoil-KoA.
Reference[uredi | uredi kod]
- ↑ Alexson, S.E.H. and Nedergaard, J. (1988). „A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria”. J. Biol. Chem. 263: 13564-13571. PMID 2901416.
- ↑ Alexson, S.E.H., Svensson, L.T. and Nedergaard, J. (1989). „NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat”. Biochim. Biophys. Acta 1005: 13-19. PMID 2570608.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.