ADAMTS 13 endopeptidaza

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ADAMTS 13 endopeptidaza
Identifikatori
EC broj 3.4.24.87
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

ADAMTS 13 endopeptidaza (EC 3.4.24.87, ADAMTS VWF razlažuća metaloproteaza, ADAMTS-13, ADAMTS13, vWF-razlažuća proteaza, VWF-CP, vWF-razlažuća proteaza, Upshaw faktor, von Willebrand faktor razlažuća proteaza, ADAMTS13 peptidaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Enzim razlaže von Vilebrandov faktor na vezi Tyr842-Met843 unutar A2 domena

Ovaj enzim pripada peptidaznoj familiji M12.

Reference[uredi - уреди | uredi izvor]

  1. Fujikawa, K., Suzuki, H., McMullen, B. and Chung, D. (2001). "Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family". Blood 98: 1662–1666. PMID 11535495. 
  2. Dong, J.F., Moake, J.L., Nolasco, L., Bernardo, A., Arceneaux, W., Shrimpton, C.N., Schade, A.J., McIntire, L.V., Fujikawa, K. and Lopez, J.A. (2002). "ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions". Blood 100: 4033–4039. PMID 12393397. 

Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]