ADAMTS 13 endopeptidaza
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| ADAMTS 13 endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.87 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
ADAMTS 13 endopeptidaza (EC 3.4.24.87, ADAMTS VWF razlažuća metaloproteaza, ADAMTS-13, ADAMTS13, vWF-razlažuća proteaza, VWF-CP, vWF-razlažuća proteaza, Upshaw faktor, von Willebrand faktor razlažuća proteaza, ADAMTS13 peptidaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Enzim razlaže von Vilebrandov faktor na vezi Tyr842-Met843 unutar A2 domena
Ovaj enzim pripada peptidaznoj familiji M12.
Reference[uredi | uredi kod]
- ↑ Fujikawa, K., Suzuki, H., McMullen, B. and Chung, D. (2001). „Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family”. Blood 98: 1662-1666. PMID 11535495.
- ↑ Dong, J.F., Moake, J.L., Nolasco, L., Bernardo, A., Arceneaux, W., Shrimpton, C.N., Schade, A.J., McIntire, L.V., Fujikawa, K. and Lopez, J.A. (2002). „ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions”. Blood 100: 4033-4039. PMID 12393397.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.